中药配伍对关木通中马兜铃酸A含量的影响

目的：运用高效液相色谱法找出同关木通配伍后，使其中马兜铃酸A含量显著降低的中药及其最佳配比。方法：关木通与筛选药物配伍后，用反相高效液相色谱法（RP-HPLC）测定马兜铃酸A吸收值判断其含量是否降低。结果：当归、丹皮、生地、熟地、大黄可显著降低关木通中马兜铃酸A的含量。其中，当归与关木通质量比为1：1，生地与关木通质量比为0．5：1，丹皮与关木通质量比为1：1是最佳配比。结论：关木通配伍上述中药后，马兜铃酸A的含量能显著降低。

The influence of compatible medicinal herbs on the content offructus aristolochiae acid A from caulis clematidis armandii

Object: To find out the medicinal herbs that can markedly reduce the content of fructus aristolochiae acid A and optimize their compatible proportion after combined with canlis clematidis armandii by RP-HPLC. Methods: After canlis clematidis armandii being compatible with selected medicinal herbs. the content of fructus aristolochiae acid A was determined by RP-HPLC to judge whether it may be reduced. Results: Radix angelicae sinensis, radix paeonia suffruticosa Andr., radix rehmanniae and radix et rhizoma rhei can markedly reduce the content of fructus aristolochiae acid A. The optimum compatible mass proportions were as follows: radix angelicae sinensis vs canlis clematidis armandii of 1:1; radix rehmanniae vs canlis clematidis armandii of 0.5:1 and radix paeonia suffruticosa Andr. vs canlis clematidis armandii of 1:1. Conclusion: After canlis clematidis armandii was being compatible with the above mentioned medicinal herbs, the content of fructus aristolochiae acid A could be markedly reduced.