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| 清热中药对高糖培养下肾小球系膜细胞增殖的影响 | |
| 引用本文： | 孙敏,孙晶,朱荃. 清热中药对高糖培养下肾小球系膜细胞增殖的影响[J]. 上海中医药杂志, 2005, 39(3): 58-59 |
| 作者姓名： | 孙敏 孙晶 朱荃 |
| 作者单位： | 安徽大学生命科学院,安徽,合肥,230029;江苏大学2004级研究生,江苏,镇江,212013;南京中医药大学国家规范化中药药理实验室,江苏,南京,210029 |
| 基金项目： | 国家科技部十五攻关课题(2001BA701A29) |
| 摘 要： | 为研究清热中药治疗糖尿病肾病的作用机理，验证中医理论对糖尿病发病机制的认识，并为临床用药提供依据。采用MTF比色法，观察具有清热作用的中药知母、生地、胡黄连和地骨皮水提物对体外高糖条件下培养的牛肾小球系膜细胞增殖的影响。结果显示，知母、生地和胡黄连对系膜细胞增殖有抑制作用，而地骨皮无明显作用。提示清热中药可能通过抑制系膜细胞的增殖从而对糖尿病肾病的发生产生一定的影响。 |
| 关 键 词： | 糖尿病肾病 系膜细胞 增殖作用 |
| 文章编号： | 1007-1334(2005)03-0058-02 |
| 修稿时间： | 2004-11-24 |
Effects of Heat-Clearing Herbs on the Proliferation of Glomeruli Mesangial Cells Induced by High Glucose |
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| SUN Min,SUN Jing,ZHU Quan. Effects of Heat-Clearing Herbs on the Proliferation of Glomeruli Mesangial Cells Induced by High Glucose[J]. Shanghai Journal of Traditional Chinese Medicine, 2005, 39(3): 58-59 | |
| Authors: | SUN Min SUN Jing ZHU Quan |
| Affiliation: | School of Life Science,Anhui UniversitySUN Min]2004 Postgraduate,Jiangsu UniversitySUN Jing]National Standard Laboratory of Pharmacology for Chinese Materia Medica,Nanjing University of Traditional Chinese MedicineZHU Quan |
| Abstract: | To study the mechanism of heat-clearing herbs in treating diabetic nephropathy and verify the theory of traditional Chinese medicine in the episode of diabetic nephropathy for clinical evidence, the glomeruli mesangial cells proliferation were induced by high glucose incubation in vitro and the effect of herbs on the proliferation were detected by MTT assay. Results: Radix Rehmanniae, Rhizoma Anemarrhenae and Picrorhiza Rhizome could inhibit the proliferation induced by high glucose, but Cortex lycil could not do. It is revealed that heat-clearing herbs can inhibit the genesis of diabetic nephropathy. |
| Keywords: | Diabetic nephropathy mesangial cell proliferation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |