唑来膦酸对妇科恶性肿瘤术后骨质疏松的疗效观察及安全性分析

目的观察唑来膦酸对妇科恶性肿瘤术后骨质疏松患者的疗效并进行不良反应监测与分析。方法选择2010年2月至2014年2月辽河油田总医院与海原县中医医院收治的120例妇科恶性肿瘤术后骨质疏松患者,采用随机双盲对照的研究设计将患者分为观察组与对照组,各60例。观察组予5mg唑来膦酸并服用钙尔奇D片,对照组给予5mg安慰剂并服用钙尔奇D片,比较两组治疗前后视觉模拟评分法(visual analogue scale/score,VAS)评分、腰椎与股骨颈骨密度以及急性期不良反应等情况。结果观察组VAS评分、腰椎与股骨颈骨密度均有显著改善(P0.05),且效果明显优于对照组(P0.05);观察组急性期不良反应发生率高达31.79%,但症状较轻且能较快缓解,并无严重不良反应。结论唑来膦酸对妇科恶性肿瘤术后骨质疏松的患者疗效明显,具有一定的安全性。

Efficacy observation and safety analysis of Zoledronic acid on osteoporosis of postoperative gynaecological manligancies

Objective To observe the curative effect as well as to monitor and analysis adverse reaction of osteoporosis treatment in patients with gynecological malignant tumor. Method 120 cases of patients who had come to the General Hospital of Liaohe Oil Field and Haiyuan County Hospital of Traditional Chinese Medicine from February 2010 to February 2014 were selected. Using randomized, double-blind and placebo-controlled study design, selected 120 cases after of gynecologic malignant tumor operation with osteoporosis. The observation group were given 5 mg of zoledronic acid with Caltrate D, the control group were given 5 mg placebo Caltrate D,Observe the two groups before and after treatment by VAS score, lumbar vertebra ,femoral neck bone mineral density and acute adverse reactions. Results After treatment,VAS score, lumbar spine and femoral neck bone mineral density were significantly improved (P<0. 05)in the observation group and were better than the control group (P<0. 05);acute stage adverse reaction rate in the observation group is as high as 31. 79%, but symptoms are light and can relieve quickly, no serious adverse reaction. Conclusion The effect of osteoporosis treatment after gynecological malignant tumor is obvious, and it has certain safety.