| 结直肠癌患者门静脉血CK20mRNA检测的临床意义 |
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| 引用本文： | 刘民生,黄志恒,杨锋,郑凯,徐民,何丽娟.结直肠癌患者门静脉血CK20mRNA检测的临床意义[J].结直肠肛门外科,2007,13(1):29-31. |
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| 作者姓名： | 刘民生 黄志恒 杨锋 郑凯 徐民 何丽娟 |
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| 作者单位： | 深圳市第二人民医院普外一科,518035 |
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| 摘 要： | 目的:检测结直肠癌患者门静脉血CK20mRNA的表达情况,探讨其临床意义.方法:用实时定量荧光逆转录聚合酶链(FQ-PCR)方法,检测了72例结直肠癌患者门静脉及周围静脉血CK20mRNA的表达.结果:结直肠癌患者门静脉血CK20mRNA表达的阳性率72%(52/72)高于周围静脉血43%(31/72)(P＜0.001),结直肠癌DukesC、D期门静脉血CK20mRNA高于A、B期(P＜0.001).结论:门静脉血CK20mRNA表达的检测比周围静脉血检测更准确、敏感,是判断体内隐性播散和愈后的可靠方法.
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| 关 键 词： | 结直肠癌 微转移 CK20mRNA FQ-PCR |
| 收稿时间： | 2006-10-25 |
| 修稿时间： | 2006年10月25日 |
The clinical significance of CK20 mRNA expression in the portal-vein blood of colorectal cancer patients |
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| Liu Minsheng;Huan Zhiheng;Yang Feng;et al.The clinical significance of CK20 mRNA expression in the portal-vein blood of colorectal cancer patients[J].Journal of Colorectal & Anal Surgery,2007,13(1):29-31. |
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| Authors: | Liu Minsheng;Huan Zhiheng;Yang Feng; |
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| Abstract: | Objective: To evaluate the clinical significance of CK20 mRNA expression in the portal-vein blood of colorectal cancer patients. Methods: Expression of CK20 mRNA was detected by FQ-PCR in portal-vein blood and peripheral blood in 72 colorectal patients. Results: The expression of CK20mRNA in portal-vein blood was significantly higher than that in the peripheral blood in every stage of colorectal cancer patients. Conclusion: It suggests that determination of CK20 mRNA in portal-vein blood is more accurate and sensitive than that in the peripheral vein blood, and it is an ideal means for evaluation of the prognosis. |
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| Keywords: | Colorectal cancers Micrometastasis CK20 mRNA FQ-PCR |
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