针刺治疗阿尔茨海默病临床随机对照试验Meta分析

目的:系统评价传统中医针刺与西药治疗阿尔茨海默病的疗效差异。方法:计算机检索PubMed、Embase、Cochrane图书馆、CNKI、VIP和万方等中外文数据库,筛选出针刺对照西药治疗阿尔茨海默病的临床随机对照试验。对符合纳入排除标准的文献评价质量,并应用Rev Man 5.2软件进行Meta分析。结果:共纳入8篇文献,349例患者;Meta分析结果显示:针灸治疗阿尔茨海默病的临床疗效[OR=1.15,95%CI(0.69,1.91)]、MMSE量表评分[MD=0.40,95%CI(-2.18,2.97)]、ADL量表评分[MD=0.60,95%CI(-0.54,1.74)]、HDS评分[MD=-0.20,95%CI(-1.19,0.80)]与西药比较相当,2组比较差异无统计学意义。结论:针刺对照西药治疗阿尔茨海默病的疗效优势尚不明确,需更多大样本高质量的临床随机对照试验进一步验证。

Meta Analysis of Randomized Controlled Clinical Trial about Acupuncture in Treating Alzheimer's Disease

Objective: To systematically assess the differences between traditional acupuncture and western medicine in treating alzheimer's disease. Methods: Randomized controlled trials (RCTs) about acupuncture compared with western medicine in treating alzheimer's disease were chosen by searching PubMed, Embase, Cochrane library, CNKI, VIP and Wanfang, the quality of the literature which met the included standard were assessed and meta analysis was performed by using RevMan 5.2 software. Results: Eight articles and 349 patients were included. The results of Meta analysis showed that the difference had no statistical meaning between both groups, while clinical effects of acupuncture in treating alzheimer's disease [OR=1.15, 95%CI (0.69, 1.91)], MMSE scaling [MD=0.40, 95%CI (-2.18, 2.97)], ADL scaling [MD=0.60, 95%CI (-0.54, 1.74)], HDS scaling [MD=-0.20, 95%CI (-1.19, 0.80)] were equivalent to these indexes of western medicine. Conclusion: The advantages of acupuncture in treating alzheimer's disease compared with western medicine are unsure, more large samples and high quality RCTs are needed to further validate the results.