| 展望受体低氧预适应在原位肝移植中的应用 |
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| 引用本文： | 梁四海,张培建,王懋莉.展望受体低氧预适应在原位肝移植中的应用[J].国际外科学杂志,2007,34(6):397-399. |
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| 作者姓名： | 梁四海 张培建 王懋莉 |
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| 作者单位： | 225001,扬州,扬州大学医学院第二临床附属医院肝胆外科 |
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| 基金项目： | 江苏省科技厅社会发展科技项目（No.BS2004536） |
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| 摘 要： | 了解原位肝移植过程中无肝期门静脉淤血引起的肠道淤血性缺氧对肝完全缺血再灌注损伤的影响以及肠道缺氧低氧耐受的内源性保护机制。采用文献回顾的方法加以综述。对肝移植受体肠道黏膜屏障功能的保护可减轻移植肝脏再灌注损伤。受体低氧预适应可能为移植肝脏再灌注损伤的保护提供一条全新的途径。
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| 关 键 词： | 肝移植 缺血再灌注损伤 肠道淤血性缺氧 受体 低氧预适应 |
| 修稿时间： | 2006-12-20 |
Prospects for recipient hypoxic preconditioning in orthotopic liver transplantation |
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| LIANG Si-Hai,ZHANG Pei-Jian,WANG Mao-Li.Prospects for recipient hypoxic preconditioning in orthotopic liver transplantation[J].International Journal of Surgery,2007,34(6):397-399. |
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| Authors: | LIANG Si-Hai ZHANG Pei-Jian WANG Mao-Li |
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| Institution: | Department of Hepatobiliary Surgery, Second Affiliated Hospital, School of Medicine, Yangzhou University, Yangzhou 225001, Jiangsu Province, China |
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| Abstract: | To study the effect of intestinal stagnant anoxia in anhepatic phase on total hepatic ischemia/ reperfusion injury during orthotopic liver transplantation and the endogenous protective mechanism of enterohypoxia tolerance to ambient hypoxia. The literature in recent years on the subject were reviewed. To protect intestinal mucosal barrier of the recipient may relieve the reperfusion injury of liver transplanted. Hypoxic preconditioning on recipient may provide a novel approach to protecting the reperfusion injury of liver transplanted. |
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| Keywords: | liver transplantation ischemia/reperfusion injury intestinal stagnant anoxia recipient hypoxic preconditioning |
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