Comparison of three different purification methods for the routine preparation of [11C] Metomidate. |
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| Authors: | Markus Mitterhauser Wolfgang Wadsak Oliver Langer Joern Schmaljohann Georg Zettinig Robert Dudczak Helmut Viernstein Kurt Kletter |
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| Affiliation: | Department of Nuclear Medicine, University of Vienna, AKH Wein, Waehringer Guertel 18-20, 1090 Vienna, Austria. markus.mitterhauser@akh-wien.ac.at |
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| Abstract: | ![]()
PET with (R)-[O-methyl-11C] metomidate ([11C] MTO) is an attractive method for the characterisation of adrenal masses discriminating lesions of adrenal cortical origin from noncortical lesions. [11C] MTO was prepared by the reaction of [11C] methyliodide with the corresponding free acid. Three purification methods have been compared. The method of choice uses preparative HPLC with a ready-to-use weak acidic solvent. |
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