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Acute renal failure in a patient with paroxysmal cold hemoglobinuria |
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| Authors: | Daljit K. Hothi Paul Bass Mary Morgan Jayshree Acharya Steve E. Humphries Rodney D. Gilbert |
| Affiliation: | (1) Regional Paediatric Nephro-Urology Service, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK;(2) Department of Cell Pathology, Southampton General Hospital, Southampton, UK;(3) Paediatric Haematology Service, Southampton General Hospital, Southampton, UK;(4) Centre for Cardiovascular Genetics, Royal Free & University College London Medical School, London, UK |
| Abstract: | Acute renal failure following auto-immune hemolysis is rare. We report a child with acute paroxysmal cold hemoglobinuria (PCH) complicated by renal failure. She was treated by peritoneal dialysis and red blood cell transfusion. After 2 weeks she had made a complete recovery with a normal blood count and renal profile, and the peritoneal dialysis catheter was removed. Extensive investigation, including an analysis of heme oxygenase-1 gene promoter region polymorphisms, failed to identify a cause for the renal failure in this patient. |
| Keywords: | Acute renal failure Heme oxygenase-1 Paroxysmal cold hemoglobinuria |
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