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| 电刺激中缝背核对大鼠应激性胃粘膜损伤的影响 | |
| 引用本文： | 郑芳 张建福. 电刺激中缝背核对大鼠应激性胃粘膜损伤的影响[J]. 徐州医学院学报, 1995, 15(3): 241-244 |
| 作者姓名： | 郑芳 张建福 |
| 作者单位： | Department of Physiology，Xuzhou Medical College，Xuzhou，Jiangsu，221002 China |
| 摘 要： | 以寒冷加束缚制备大鼠应激必占膜损伤模型，观察电刺激中缝背核对应激性胃粘膜损伤的影响，结果表明：（１）电刺激ＤＲＮ能明显地减轻应激性胃粘膜损伤，这一效应可被腹腔注射５－ＨＴ合成阻断剂对氯苯丙氮酸所逆转；（２）电解损毁ＤＲＮ可使就激性胃占膜损伤加重，向ＤＲＮ内胞体毒性剂Ｌ－谷氨酸与电解损毁ＤＲＮ的效应相同。 |
| 关 键 词： | 中缝背核 室旁核 胃粘膜损伤 大鼠 电刺激 |
EFFECT OF ELECTRIC STIMULATION OF DORSAL RAPHE NUCLEUS ON STRESS GASTRIC MUCOSAL LESION IN RATS |
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| Zheng Fang,Zhang Jianfu. EFFECT OF ELECTRIC STIMULATION OF DORSAL RAPHE NUCLEUS ON STRESS GASTRIC MUCOSAL LESION IN RATS[J]. Acta Academiae Medicinae Xuzhou, 1995, 15(3): 241-244 | |
| Authors: | Zheng Fang Zhang Jianfu |
| Abstract: | The effect of electric stimulation of dorsal raphe nucleus(DRN)on gastric mucosal lesion induced by RWIS(restraint water-immersion stress)in rats was investigated.The results were as follows:(1)Electric stimulation of the DRN obviously decreased the stress gastric mucosal lesion and the effect could be attenuated by PCPA I.P.Electric ablation of DRN intensified the stress gastric mucosal lesion significantly.(2)Both microinjection of L-glutanate into DRN and PCPA I.P.produced effects similar to that of electric ablation of DRN.(3) After the destruction of DRN, the aggravating effect of electric stimulation of PVN on stress gastric mucosal lesion was attenuated.These results indicate that the DRN is one of the specific areas in CNS capable of decreasing the stress gastric ulcer and plays an important role in increasing the effect of electric stimulation of PVN on stress gastric mucosal lesion. |
| Keywords: | dorsal raphe nucleus (DRM) paraventricular nucleus(PVN) stress gastric mucosal lesion rat |
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