VEGF-C 在乳腺癌组织中的表达及意义

目的：探讨血管内皮生长因子-C（VEGF—C）在乳腺癌组织中的表达及意义。方法：应用Elivision二步免疫组化法，观察45例乳腺癌和7例乳腺良性增生性病变组织中VEGF—C的表达情况、ER和PR、FⅧ阳性的血管密度，分析其与临床病理指标之间的关系。结果：45例乳腺癌组织中有25例VEGF—C表达阳性，阳性率为55．6％，而7例乳腺良性病变中有4例阳性，阳性率为57．1％，两者之间无显著差异（P=1．00）；45例乳腺癌组织中VEGF—C的表达与患者年龄、肿瘤大小、淋巴结转移及临床分期之间均无统计学相关性（P均大于0．05）；VEGF—C的表达与MVD之间呈显著正相关（r=0．325，P=0．030）；VEGF—C的表达与ER（P=0．248）及PR（P=0．071）的表达之间无显著性相关。结论：VEGF—C与MVD呈显著正相关，提示其有促进血管生成的作用。VEGF—C的表达与激素受体之间无显著相关性，其表达可能不受激素的调控。

Expression of vascular endothelial growth factor-C and its significance in breast carcinoma tissue

Objective:To investigate the expression of VEGF-C and its significance in primary breast carcinomas.Methods:VEGF-C expression was trsted by immunohistochemistry in 7 benign proliferative breast tissue samples and 45 breast cancers.Results:No significant difference in VEGF-C expression was observed between benign and malignant breast tissues(P=1.00).There was a significant correlation between VEGF-C and MVD(P=0.030),but no association was seen between VEGF-C and lymph node status,patient age,tumor size,estrogen receptor status,progesterone receptor status,clinical stage.Conclusion:Vascular endothelial growth factor-C promotes angiogenesis,but its expression showed no significant correlation with clinical-pathological parameters of breast cancer.No significant relationship between VEGF-C and ER,PR status,suggest that the expression of VEGF-C may not be regulated by sex hormone.