硬皮病中西医治疗的研究进展

综述近年来硬皮病的发病机制与中西医治疗方法.硬皮病是一种主要累及皮肤、黏膜组织并以纤维化和硬化为主要特征的结缔组织疾病,自身免疫改变和纤维化是该病的突出特征,其发病机制涉及血管异常、结缔组织异常、免疫改变等.西医治疗硬皮病通常采用药物硝苯地平、泼尼松、波生坦、青霉胺、秋水仙碱、伊洛前列腺素、环磷酰胺、霉酚酸酯等,同时结...

Advances in Research on Scleroderma Treated with Traditional Chinese Medicine and Western Medicine

The recent research progress in the pathogenesis and traditional Chinese medicine and western medicine treatment for scleroderma was reviewed. Scleroderma is a kind of connective tissue disease which mainly involves the skin and mucous tissues,and is characterized by fibrosis and sclerosis. The changes of autoimmunity and fibrosis are the specific pathological features of scleroderma. The pathogenesis of scleroderma is related with the vascular disorders,connective tissue disorders,and immune disorders. The western medicine treatment for scleroderma can be mainly achieved by medication of nifedipine,prednisone,bosentan,penicillamine,colchicine,iloprost,cyclophosphamide,and mycophenolate mofetil,and can be assisted by phototherapy. The traditional Chinese medicine treatment for scleroderma can be through the medication of Gegen Decoction, Buzhong Yiqi Decoction,modified Yanghe Decoction,Danggui Sini Decoction,and Pibi Recipe,and can be combined with the external therapies of steaming and washing,external application of tincture,hot-compressing,acupuncture,and moxibustion,which can bring about satisfactory effect. The future research of scleroderma should focus on the further exploration of pathogenesis,and the screening of effective methods for relieving the symptoms induced by the immunodeficiency. The establishment of precise therapy for the complications of specific organs and the individualized management will be the effective method for reducing complications and improving prognosis.