阿替普酶静脉溶栓桥接动脉机械取栓治疗急性脑梗死患者的效果

目的:观察阿替普酶静脉溶栓桥接动脉机械取栓治疗急性脑梗死(ACI)患者的效果。方法:回顾性分析2019年2月至2020年10月该院收治的87例ACI患者的临床资料,依照治疗方案不同分为对照组(n=42)和观察组(n=45)。对照组采用阿替普酶静脉溶栓治疗,观察组采用阿替普酶静脉溶栓桥接动脉机械取栓治疗,比较两组血管再通率、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分和不良事件发生率。结果:观察组血管再通率为84.44%(38/45),高于对照组的42.86%(18/42),差异有统计学意义(P<0.05);治疗后1 d、出院时,观察组NIHSS评分均低于对照组,差异有统计学意义(P<0.05);出院后30、60、90 d,观察组mRS评分均低于对照组,差异有统计学意义(P<0.05);两组不良事件发生率比较,差异无统计学意义(P>0.05)。结论:阿替普酶静脉溶栓桥接动脉机械取栓治疗ACI患者,可提高血管再通率,降低NIHSS、mRS评分,效果优于单纯阿替普酶静脉溶栓治疗。

Effects of Alteplase intravenous thrombolysis bridging arterial mechanical thrombectomy in treatment of patients with acute cerebral infarction

Objective:To observe effects of Alteplase intravenous thrombolysis bridging arterial mechanical thrombectomy in treatment of patients with acute cerebral infarction(ACI).Methods:A retrospective analysis of the clinical data of 87 ACI patients admitted to the hospital from February 2019 to October 2020 was performed.According to different treatment plans,they were divided into control group(n=42)and observation group(n=45).The control group was treated with Alteplase intravenous thrombolysis,while the observation group was treated with Alteplase intravenous thrombolysis bridging arterial thrombectomy.The vascular recanalization rate,the National Institutes of Health Stroke Scale(NIHSS)score,the modified Rankin scale(mRS)score,and the incidence of complications were compared between the two groups.Results:The vascular recanalization rate in the observation group was 84.44%(38/45),which was higher than 42.86%(18/42)in the control group,and the difference was statistically significant(P<0.05).One day after the treatment and at discharge,the NIHSS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).30,60,and 90 days after discharge,the mRS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:Alteplase intravenous thrombolysis bridging arterial mechanical thrombectomy in the treatment of the ACI patients can increase the vascular recanalization rate and reduce the NIHSS score and the mRS score.Moreover,it is superior to single Alteplase intravenous thrombolysis.