基于microRNA探讨中医药在骨关节炎软骨细胞衰老中的调控作用

miroRNA通过调控基因表达水平影响信号通路,在软骨细胞发育和软骨内稳态中发挥着关键作用.中医药防治骨关节炎的潜在作用机制可能与调控软骨细胞衰老相关microRNA有关.补益肾气、活血化瘀类中药可通过调控miR-140、miR-146a、miR-155等软骨细胞衰老相关microRNA及其下游相关靶基因的表达,抑制软...

Exploring the Regulatory Effect of Chinese Medicine on Chondrocyte Aging in Osteoarthritis Based on microRNA

miroRNA affects signal pathway by regulating gene expression level, and plays a key role in chondrocyte development and cartilage homeostasis.The potential mechanism of Chinese medicine in the prevention and treatment of osteoarthritis may be related to the regulation of chondrocyte aging related microRNA.Chinese medicines such as tonifying kidney qi, promoting blood circulation and removing blood stasis can inhibit chondrocyte aging and inflammation and prevent osteoarthritis by regulating the expression of chondrocyte aging related microRNA and its downstream target genes such as miR-140,miR-146 a and miR-155.The therapeutic effect of acupuncture and moxibustion on chondrocyte aging in osteoarthritis has also been confirmed.However, at present, the molecular mechanism of Chinese medicine in the prevention and treatment of osteoarthritis has not been clarified, the specific relationship between microRNA and chondrocyte aging has not been clarified, the research on external treatment of Chinese medicine such as massage and acupuncture is insufficient, and the research methods and means of Chinese medicine intervention are limited.Therefore, in the future, the research on the regulation of microRNA by Chinese medicine can focus on the internal and external pathogenesis of osteoarthritis, explore the modern scientific mechanism of tonifying kidney qi, promoting qi and activating blood circulation from the perspective of molecular biology, explain the potential mechanism of Chinese medicine in the prevention and treatment of osteoarthritis, and provide new ideas for clinical treatment.