他克莫司软膏联合窄谱中波紫外线治疗白癜风疗效观察

目的探讨他克莫司软膏联合窄谱中波紫外线(NB-UVB)治疗白癜风的疗效和安全性。方法82例白癜风患者随机分成两组。治疗组43例,外用他克莫司软膏,2次/d,NB-UVB光疗,每周2次,疗程16周。对照组39例单纯予NB-UVB光疗,用法同上。结果治疗组有效率为72.1%,对照组为48.7%,两组有效率差异有显著性(P<0.05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组(P<0.05),两组肢端皮损疗效差异无显著性(P>0.05)。患者均未出现严重不良反应。结论他克莫司软膏联合NB-UVB治疗位于面颈部、躯干和四肢的白癜风疗效好,不良反应少。

Efficacy Observation of Tacrolimus Ointment Combined with Narrow-band Ultraviolet B Phototherapy in the Treatment of Vitiligo

Objective To investigate the efficacy and safety of tacrolimus ointment combined with narrow-band ultraviolet B(NB-UVB)phototherapy in the treatment of vitiligo. Methods Eighty-two patients with vitiligo were divided into two groups randomly. Forty-three patients of treatment group were treated twice daily with tacrolimus ointment combined with NB-UVB phototherapy twice weekly for 16 weeks. Similarly, thirty-nine patients of control group were only treated with NB-UVB phototherapy twice weekly for 16 weeks. Results The total effective rate of treatment group was 72.10% and that of control group was 48.70%. There was significant difference between two groups(P<0.05).The effect of treatment group is superior to that of control group to the vitiligous lesions located on face neck trunk and extremities(P<0.05).However, there was not statistical significance between two groups in the effective rate of acral lesions(P>0.05).No serious adverse events were recorded in both groups. Conclusion The combination of tacrolimus ointment with NB-UVB phototherapy can represent an effective and well-tolerated approach to vitiligo located on face neck trunk and extremities.