腹膜透析患者低肌肉组织指数相关影响因素分析

目的:探讨规律腹膜透析(腹透)患者低肌肉组织指数(lean tissue index,LTI)的发生率及相关影响因素.方法:选择2019年10月至2020年5月在上海健康医学院附属嘉定区中心医院接受规律腹透治疗的患者.应用多频生物电阻抗技术测量入选患者的LTI,采集人口统计学资料、生化指标,评估患者的腹膜转运特性及透析...

Risk factors of low lean tissue index in peritoneal dialysis patients

Objective: To investigate the incidence of low lean tissue index (LTI) and analyze the risk factors of low LTI in peritoneal dialysis (PD) patients.Methods: PD patients in Jiading District Central Hospital Affiliated to Shanghai University of Medicine & Health Sciences from October 2019 to May 2020 were included. Demographic data of patients were collected and biochemical parameters were measured. LTI was measured by bioimpedance spectroscopy. Patients with an LTI less than 10% of the referenced range for their age and gender were considered to have a low LTI. Multivariate logistic regression was used to analyze the risk factors of low LTI.Results: A total of 104 PD patients were included, and low LTI was detected in 49 patients (47.1%). Compared to the normal LTI group, the red cell distribution width (RDW), interleukin-6 (IL-6) concentration, subjective global assessment(SGA) grade, and overhydration in the low LTI group were increased (P<0.05), whereas body mass index (BMI) was decreased (P<0.05). Multivariate logistic regression showed that IL-6 concentration (OR=1.098, 95%CI 1.024-1.177, P=0.009), RDW (OR=1.873, 95%CI 1.183-2.965, P=0.007), BMI (OR=0.787, 95%CI 0.679-0.911, P=0.001), and the SGA grade (OR=6.334, 95%CI 1.568-25.295, P=0.009) were independent risk factors of LTI.Conclusions: Low LTI is common in PD patients, higher IL-6, RDW, SGA grade, and lower BMI are independent risk factors of low LTI.