| 口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶活性的研究 |
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| 引用本文： | 马安宇,张辉,朱楼英,毛宇飞. 口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶活性的研究[J]. 北方药学, 2015, 0(4): 101-102 |
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| 作者姓名： | 马安宇 张辉 朱楼英 毛宇飞 |
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| 作者单位： | 1. 金华市食品药品检验检测研究院 金华 321000;2. 金华职业技术学院医学院 金华 321000 |
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| 基金项目： | 金华市科技局科研项目:计划编号:2013-3-087 |
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| 摘 要： | 目的：研究口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶（GSH-PX）的活性。方法：用90%苯酚溶液灼烧豚鼠左侧面颊，造成口腔溃疡模型，观察豚鼠口腔溃疡模型的溃疡面积、溃疡程度及溃疡组织病理变化，测定血清中GSH-PX活性。结果：用苯酚溶液造豚鼠口腔溃疡模型成功，d1～d5，模型组与空白组相比，口腔溃疡程度显著，血清中GSH-PX活性显著降低（P<0.01）。口腔溃疡豚鼠随着时间的变化溃疡面积逐渐缩小，血清中GSH-PX活性逐渐增强。结论：血清中GSH-PX对口腔溃疡的自愈有促进作用。
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| 关 键 词： | 口腔溃疡豚鼠 谷胱甘肽过氧化物酶 |
Study on Glutathione Peroxidase Activity in Serum of the Oral Ulcer Guinea Pig |
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| Ma Anyu , Zhang Hui , Zhu Louying , Mao Yufei. Study on Glutathione Peroxidase Activity in Serum of the Oral Ulcer Guinea Pig[J]. BEIFANG YAOXUE, 2015, 0(4): 101-102 |
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| Authors: | Ma Anyu Zhang Hui Zhu Louying Mao Yufei |
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| Affiliation: | Ma Anyu;Zhang Hui;Zhu Louying;Mao Yufei;Jinhua Institute for Food and Drug Control;Jinhua college of profession and technology; |
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| Abstract: | Objective:To investigate the activity of glutathione peroxidase (GSH-PX)in serum of the oral ulcer guinea pig. Methods:Guinea pig model with oral ulcer was induced by burning the left cheek with 90% phenol solution. The area of ulcer, the degree of ulcer and the changes of organization pathological were observed in guinea pig model of oral ulcer. The activity of GSH-PX was determined in serum. Results:The phenol-induced guinea pig has been established successfully.1~5d, compared with blank control group, the degree of ulcer in the model group was obvious, the activity of GSH-PX was decreased significantly(P<0.01).Along with the changes of time,the area of ulcer was decreased gradually, the activity of GSH-PX in serum was increased gradually. Conclusion:The GSH-PX in serum has a promoting role in oral ulcer healing. |
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| Keywords: | The oral ulcer guinea pig Glutathione peroxidase |
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