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| Polymorphism of the DNA repair gene XPA and susceptibility to lung cancer | |
| 引用本文： | Jinfu Zhu,Zhibin Hu,Hongxia M,Xiang Huo,Lin Xu,Jiannong Zhou,Hongbing Shen,Yijiang Chen. Polymorphism of the DNA repair gene XPA and susceptibility to lung cancer[J]. 南京医科大学学报(自然科学版), 2005, 19(4): 173-176 |
| 作者姓名： | Jinfu Zhu Zhibin Hu Hongxia M Xiang Huo Lin Xu Jiannong Zhou Hongbing Shen Yijiang Chen |
| 作者单位： | [1]Department of Thoracic ＆ Cardiac Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China [2]Department of Epidemiology ＆ Biostatistics, School of Public Health, Nanjing Medical University,Nanjing 210029, China [3]Department of Thoracic Surgery, Jiangsu Cancer Hospital,Nanjing 210009, China |
| 基金项目： | National Natural Science Foundation of China （30371240） and Innovative Foundation of Nanjing Medical University（CX2003005） |
| 摘 要： | Objective： To study the relationship between one polymorphism in the promoter of the DNA repair gene XPA and the susceptibility to lung cancer. Methods： Genotypes were determined by the PCR-restriction fragment length polymorphism （PCR-RFLP） method in 310 histologically-confirmed lung cancer cases and 341 age and sex frequency-matched cancer-free controls. Results： The XPA A23G genotype frequencies were 27.1% （AA）, 42.9% （AG）, and 30.0% （GG） in case patients and21.1% （AA）, 5218% （AG）, and 26.1% （C-G） in control subjects. Multivariate logistic regression analysis revealed that individuals carrying at least one 23G variant allele （AG ＋ GG genotypes） had a significantly decreased risk for lung cancer （adjusted OR = 0.66; 95 % CI = 0.44- 0.98） compared with the wild-type genotype （23AA）. Stratified analysis showed that the protective effect was more evident in subjects with a family history of cancer. Conclusion： These results suggest that the XPA A23G polymorphism may have a role in lung cancer susceptibility in this study population. |
| 关 键 词： | 基因多态性 DNA修复基因 XPA 易感性 肺癌 |
| 收稿时间： | 2004-11-23 |
Polymorphism of the DNA repair gene XPA and susceptibility to lung cancer |
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| Jinfu Zhu,Zhibin Hu,Hongxia M,Xiang Huo,Lin Xu,Jiannong Zhou,Hongbing Shen,Yijiang Chen. Polymorphism of the DNA repair gene XPA and susceptibility to lung cancer[J]. Acta Universitatis Medicinalis Nanjing, 2005, 19(4): 173-176 | |
| Authors: | Jinfu Zhu Zhibin Hu Hongxia M Xiang Huo Lin Xu Jiannong Zhou Hongbing Shen Yijiang Chen |
| Abstract: | Objective: To study the relationship between one polymorphism in the promoter of the DNA repair gene XPA and the susceptibility to lung cancer. Methods: Genotypes were determined by the PCR-restriction fragment length polymorphism (PCR-RFLP) method in 310 histologically-confirmed lung cancer cases and 341 age and sex frequency-matched cancer-free controls. Results: The XPA A23G genotype frequencies were 27.1% (AA), 42.9% (AG), and 30.0% (GG) in case patients and 21.1% (AA), 52.8% (AG), and 26.1% (GG) in control subjects. Multivariate logistic regression analysis revealed that individuals carrying at least one 23G variant allele (AG+GG genotypes) had a significantly decreased risk for lung cancer (adjusted OR=0.66; 95%CI=0.44-0.98) compared with the wild-type genotype (23AA). Stratified analysis showed that the protective effect was more evident in subjects with a family history of cancer. Conclusion: These results suggest that the XPA A23G polymorphism may have a role in lung cancer susceptibility in this study population. |
| Keywords: | lung cancer XPA gene single nucleotide polymorphism genetic susceptibility |
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