血清 ALT水平对冠心病患者病情的预测价值研究

目的研究血清丙氨酸氨基转移酶（ALT）水平对冠心病患者病情的预测价值。方法对50例不稳定型心绞痛患者（A组）、52例稳定型心绞痛患者（B组）以及53例健康体检者（C组）分别进行血清ALT水平检测，分析冠心病患者病变程度与其的相关性。结果3组患者血清ALT水平对比，差异均具有统计学意义（P〈0．05），A组、B组患者的血清ALT水平均显著高于C组，A组血清ALT水平、冠脉狭窄程度积分（Gensini积分）显著高于B组（均P〈0．05）；Person相关分析显示，冠心病患者的Gensini积分与血清ALT水平呈显著正相关（P〈0．05）；多元回归分析显示，冠心病患者血清ALT水平对Gensini积分的变化，均具有显著的影响（P〈0．05）。结论冠心病患者的动脉粥样硬化病变程度与血清ALT水平有关，病变程度越严重，则血清ALT水平越高，其对患者的病情具有较高的预测价值。

Predictive value of serum alanine transaminase level of the severity of patients with coronary heart disease

Objective To investigate the predictive value of serum alanine transaminase level of the severity in pa- tients with coronary heart disease. Methods The levels of ALT in 50 cases of patients with unstable angina pectoris （group A）, 52 cases of patients with Stable angina pectoris（group B） and 53 cases of healthy subject（group C） were measured respectively,and the relationship between severity of coronary artery disease and serum alanine transaminase level was analyzed. Results The differences of serum alanine transaminase level in three groups were statistically signifi- cant （P〈0.05）. The serum alanine transaminase level in group A and group B were all significantly higher than those of group C and the coronary narrow degree integral（Gensini score）, serum alanine transaminase level in group A were all significantly higher than those of group B（P〈0.05）. After Person correlation analysis, the serum alanine transaminase level of patients with CHD were positively related with Gensini score（P〈0. 05）. Multiple regression analysis showed that, the Gensini score of patients with CHD was effected significantly by the serum alanine transaminase level（P〈0.05）. Conclusion The severity of atherosclerosis in patients with CHD is related with the serum alanine transaminase level, the more serious in atherosclerosis, the higher in the serum alanine transaminase level,and it has a high predictive value in the severity in patients with coronary heart disease.