不同降压药物对老年高血压患者脉搏波速度改善作用的比较

目的：评价替米沙坦、氨氯地平、氢氯噻嗪三种不同类型降压药对轻中度原发性高血压患者肱踝脉搏波速度（baPWV）的影响。方法：135例1～2级原发性高血压患者，随机分为3组：替米沙坦组（40mg／d，n=48）、氨氯地平组（5mg／d，n=45）、氢氯噻嗪组（12．5mg/d，n=42），治疗4周后，如血压仍高于140／90mmHg（1mmHg=0．133kPa），剂量加倍，疗程共12周。观察治疗前后血压及脉搏波传导速度的变化。结果：治疗12周后替米沙坦、氨氯地平及氢氯噻嗪组血压均有明显降低（P〈0．05），但各组间的血压变化差异无统计学意义（P〉0．05）；替米沙坦组和氨氯地平组baPWV均明显下降（P〈0．05），而氢氯噻嗪组治疗前后baPWV差异无统计学意义（P〉0．05）。结论：替米沙坦及氨氯地平均能改善轻中度高血压患者酌动脓掸性日此种作用部分涯千茸隆压以外的颜．制．

Effect of various antihypertensive drugs on the improvement of pulse wave velocity in patients with light-to-moderate essential hypertension

Objective： To evaluate the effects of Telmisartan, Amlodipine and Hydrochlorothiazide on brachial-ankle pulse wave velocity （baPWV） in patients with light-to-moderate essential hypertension Methods： one hundred and thirtyfive patients with 1 - 2 grade hypertension group were randomly divided to Telmisartan group （40 mg/d, n =48）, Amlodipine group （5 mg/d, rt =45） and Hydrochlorothiazide group （12.5 mg/d, n = 42）. Four weeks after treatment, doses were doubled if blood pressure was still more than 140/90 mm Hg （ 1 mm Hg =0. 133 kPa）. Blood pressure level and baPWV were determined in baseline and 12 weeks after treatment. Resuits ： Blood pressure was decreased significantly in Tehnisartan, Amlodipine and I-Iydrochlorothiazide groups with no significant differences among them （P 〈 0.05）. A significant reduction of baPWV were found in patients treated by Telmisartan and Amlodipine with no changes in patients treated by Hydrochlorothiazide （ P 〉 0.05）. Conclusion： Telmisartan and Amlodipine were effective in improving the elasticity of arteries in patients with mild-tomoderate hypertension, the mechanism of which is not only due to blood pressure control.