Efficacy and safety of Huangkui capsule for diabetic nephropathy: A protocol for systematic review and meta-analysis |
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| Authors: | Wenrong An Yanqin Huang Shouqiang Chen Tao Teng Juan Liu Yunsheng Xu |
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| Affiliation: | aFirst College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China;bDepartment of Endocrine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China;cDepartment of Endocrine, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China;dShandong Rehabilitation Research Center, Jinan, China. |
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| Abstract: | Background:Diabetic nephropathy (DN) is 1 of the most serious complications of diabetes mellitus and the leading cause of end-stage renal disease in the world. Huangkui capsule, extracted from Abelmoschus manihot (L.) medic (AM), has been widely used to treat DN. However, there is no consensus on the efficacy of Huangkui capsule for DN. This study aims to perform meta-analysis to systematically review the efficacy and safety of Huangkui capsule.Methods:The following 9 electronic databases will be comprehensively searched: PubMed, web of science, MEDLINE, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Database, Wanfang data, and Chinese BioMedicine Literature Database. The retrieval time is from their inception to May 2021. According to the inclusion and exclusion criteria, 2 reviewers independently completed the study selection, data extraction, risk of bias assessment, and data synthesis. Review Manager Version 5.3 software will be used to conduct meta-analysis.Results:This study provides a high-quality synthesis to assess the efficacy of Huangkui capsule for treating diabetic nephropathy.Conclusion:The result of this systematic review will provide objective evidence-based basis to judge the effectiveness and safety of Huangkui capsule on diabetic nephropathy. |
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| Keywords: | diabetic nephropathy Huangkui capsule meta-analysis protocol systematic review |
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