Plasma amino acids in total parenteral nutrition comparison of continuous and cyclic parenteral nutrition |
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| Affiliation: | 1. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran;2. Advanced Therapy Medicinal Product Technology Development Center (ATMP-TDC), Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran;3. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;4. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran;5. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran;6. Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran;7. Department of Diabetes, Obesity, and Metabolism, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran |
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| Abstract: | ![]()
Cyclic nocturnal total parenteral nutrition (TPN) is a widely used technique but its metabolic consequences have not been fully investigated. The aim of this work was to investigate the influence of infusion rhythm on the plasma amino-acid profile in 12 subjects. During two successive 7-day periods and in a randomly chosen order, they received either standard continuous TPN (TPNCo), i.e., 24 h a day or cyclic TPN (TPNCy), i.e., between 5 p.m. and 9 a.m. Caloric and nitrogen supplies were identical in both periods. Plasma amino-acids were analysed at 8:30 a.m. and 4:30 p.m. on the last day of each infusion period. In contrast to the stability observed in TPNCo, TPNCy led to considerable variations of plasma amino-acid concentrations, creating a profile close to that observed in normal oral feeding conditions. Total 24 h urinary amino-acid elimination and the nitrogen balance did not differ between the two types of TPN. These results show that TPNCy induces a metabolic profile close to physiological conditions. |
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