Hepatitis B vaccination in healthy Chinese adults with low dose regimens |
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| Affiliation: | 1. Division of Gastroenterology, Departments of Medicine Veterans General Hospital and National Yang-Ming Medical College, Taipei, Taiwan, Republic of China;2. Division of Gastroenterology, Departments of Pediatrics, Veterans General Hospital and National Yang-Ming Medical College, Taipei, Taiwan, Republic of China;1. National Immunization Programme, Chinese Center for Disease Control and Prevention, No. 27 Nanwei Road, Beijing 100050, China;1. Department of Hepatobiliary Medicine, Shanghai Public Health Clinical Center of Fudan University, China;2. Scientific Research Center, Shanghai Public Health Clinical Center of Fudan University, China;3. Department of Clinical Pathology, Shanghai Public Health Clinical Center of Fudan University, China;1. Complejo Hospitalario Universitario de Badajoz, Badajoz, España;2. Clínicas de HD FMC, Extremadura, España |
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| Abstract: | ![]()
Three hundred seronegative healthy Chinese adults were divided randomly into three groups to receive 5, 2 and 1 μg of Pasteur's hepatitis B vaccine on a four dose schedule. No difference between the three groups was observed in the antibody to hepatitis B surface antigen (anti-HBs) response rate (96, 92 and 94%, respectively) a month following the fourth dose of vaccination. Young vaccinees had a faster and higher anti-HBs response than older ones. There was no difference in antibody response rate by sex. This study shows a good immunogenic effect for low dose hepatitis B vaccine in Chinese adults. The use of low dose (1 μg) hepatitis B vaccine in susceptible adults would make mass hepatitis B vaccination more economically feasible. |
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