孕妇生殖道支原体感染的临床干预试验

目的：探索孕妇生殖道支原体感染与异常围产结局的病因学关系。方法：经产前检查支原体阳性妇488例,随要分成红霉素干预组和非干预组,比较两组间孕妇支原体感染阴转率,母婴传播率和异常围产结局的发生率,结果：红霉素干预组解脲支原体（Uu)的阴转率为67．3％（128／190）,明显高于非干预组的25．6％（50／195）,P＜0．05,非干预组Uu的母婴传播率为46．2％（90／195）,干预组降至25．2％（48／190）,P＜0．05,结论;红霉素干预措施能有效地降低孕妇解脲支原体感染,阻断其母传播,降低与支原体感染有关的异常围产结局。

Clinic intervention study on urogenital mycoplasma infection of pregnant women

Objective To explore the hypothesis of pathogenic relationship between urogenital mycoplasma infection and adverse perinatal outcomes. Methods Four hundred and eighty eight mycoplasma positive pregnant women detected by culture method were randomly divided into erythromycine intervention group and non intervention group. Comparison was made on rate of reverse sero conversion, of vertical transmission to mycoplasma and adverse perinatal outcomes incidence between groups. Results Ureaplasma urealyticum sero conversion rate and rate of vertical transmission in intervention group were significantly lower than in non intervention group ( P < 0.05 ). The incidences rates of preturm labor,post partum fever,puerperal infection and neonate pneumonia in intervention group were significantly lower than in non intervention group ( P < 0.05 ). Conclusion Erythromycin is effective in control of ureaplasma urealyticum infection among pregnant women through cutting off vertical transmission passway and lowering adverse perinatal outcomes against ureaplasma urealyticum.