沙利度胺加地塞米松治疗复发性多发性骨髓瘤的临床观察

目的观察沙利度胺加地塞米松治疗复发性多发性骨髓瘤的疗效.方法应用沙利度胺加地塞米松治疗复发性多发性骨髓瘤15例.为沙利度胺75～150mg/d,晚饭后1次顿服,1周后增加至200～300mg/d（增量至200mg分两次口服）,第3周以300mg维持至第10周;其间地塞米松予3mg/d晨服,至第6周开始减量,每周减0.75mg,第9周以0.375mg至第10周,与沙利度胺同时停药.10周为1疗程.结果1疗程结束后有7例患者部分缓解,4例进步,4例无效,总有效率达73%.结论沙利度胺加地塞米松治疗复发性多发性骨髓瘤疗效好,值得进一步观察总结.

Clinical Observation of the Combination of Thalidomide and Dexamethasone for the Treatment of Recurrent Multiple Myeloma

Objective To observe the efficacy and side effect of thalidomide and dexamethasone for the treatment of recurrent multiple myeloma.Method Fifteen patients were treated with thalidomide and dexamethasone.Treatment protocol was as following.Thalidomide was administered at the dose of 75mg to 150mg after supper every day,after a week,200 mg to 300 mg/d （200 mg orally twice a day）,after three weeks 300 mg for seven weeks,and associated with dexamethasone administered orally at the dose of 3 mg/d every morning, dexamethasone was reduced after one and a half months,every week 0.375 mg was reduced, ten weeks was a cycle.Result A fall in Para protein levels of greater than 40% was observed in seven of the 15 patients.the remaining four showed disease static or progression.Conclusion Thalidomide and dexamethasone is a feasible and effective method in the treatment of recurrent multiple meyloma,is worth observing further.