Effects of cured dentin bonding materials on human monocyte viability

OBJECTIVES: Dentin Bonding Agents (DBAs) have been proposed as root-end filling materials. This study examined the effect of polymerized DBAs on human monocyte viability. STUDY DESIGN: Monocytes were directly isolated from peripheral blood and being exposed to cured Scotch bond I (Single Bond) and Prime & Bond in different time intervals (36 and 72 hours). The viability of monocytes was determined by MTT assay. RESULTS: Viability of the cells was time dependent. There was no significant difference between the effect of 2 DBAs on monocytes. CONCLUSION: Results indicate that DBAs in polymerized form can alter the viability of monocytes and decrease it within time.