乳腺癌激素受体、CerbB-2、P53、nm23基因的表达及与临床病理特征的关系

目的:探讨雌激素受体(ER)、孕激素受体(PR)及C-erbB-2、P53、nm23基因在乳腺癌组织中的表达及其与临床病理特征之间的关系。方法:用免疫组织化学S-P法检测113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23的表达。并结合乳腺癌临床病理特征进行分析。结果:113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23阳性表达率分别为49.6%、39.8%、59.3%、40.7%和71.7%,与临床分期、肿瘤大小、病理类型、年龄无关(P>0.05);C-erbB-2、P53阳性表达率与腋淋巴结转移呈正相关(P<0.05)。nm23阳性表达率与腋淋巴结转移呈负相关(P<0.05)。ER和(或)PR、nm23阳性组乳腺癌复发率低于阴性组(P<0.05)。C-erbB-2、p53阳性组乳腺癌复发率高于阴性组(P<0.05)。C-erbB-2的表达在ER、PR阴性组高于阳性组(P<0.05)。结论:联合检测ER、PR与C-erbB-2、P53、nm23表达对判断乳腺癌的预后、指导临床治疗具有十分重要的意义。

Expression ofER,PR, C-erbB-2,P53,nm23 in Breast Carcinoma and Their Relationships with Clinicopathology

Objective To explore expressions of ER,PR ,C-erbB-2,p53,nm23 in breast carcinoma and their relationships with clinicopathology.Methods The expression of ER,PR,C-erbB-2,P53 and nm23 was detected by S-P immunohistochemical method in 113 cases of breast carcinoma,and their relationship with clinicopathology was analysed.Results Positive expression rates of ER,PR,C-erbB-2,P53 and nm23 were 49.6%、39.8%、59.3%、40.7% and 71.7% respectively,There was no correlation between the positive expressions of ER、PR、C-erbB-2,p53 and nm23 with clinical staging,tumor diameter,histological types and patient age(P>0.05).The expressions of C-erbB-2 and p53 were correlated positively with lymph node metastasis(P<0.05).The expression of nm23 was correlated negatively with lymph node metastasis(P<0.05).The recurrence rates of the carcinomas with positive expression of ER/PR and nm23 were lower than those with negative expression(P<0.05).On the contrary,the relapse rates of the carcinomas with positive expression of C-erbB-2 and p53 were superior to those with negative expression(P<0.05). The positive expression rate of C-erbB-2 was higher in the group with positive expression of ER and PR than negative group(P<0.05).Conclusion Combined detection of the expression of ER,PR,C-erbB-2,P53 and nm23 in breast carcinoma tissue play a important role in judging prognosis and guiding clinical treatment.