| 电针对慢性情绪应激焦虑大鼠中枢单胺递质与γ-氨基丁酸失平衡的调节作用 |
| |
| 引用本文： | 周奇志,赵纪岚,蔡定均,余曙光,魏焦禄,吴巧凤,彭晓华,王薇,徐海洋.电针对慢性情绪应激焦虑大鼠中枢单胺递质与γ-氨基丁酸失平衡的调节作用[J].中华中医药杂志,2008,23(10). |
| |
| 作者姓名： | 周奇志 赵纪岚 蔡定均 余曙光 魏焦禄 吴巧凤 彭晓华 王薇 徐海洋 |
| |
| 作者单位： | 成都中医药大学针灸推拿学院,成都610075 |
| |
| 基金项目： | 成都中医药大学针灸推拿学重点学科科研开放基金，成都中医药大学校科研和教改项目，四川省教育厅资助项目 |
| |
| 摘 要： | 目的:研究电针对慢性情绪应激(chronic emotional stress,CES)焦虑大鼠中枢单胺类神经递质与γ-氨基丁酸(γ-aminobutyric acid,GABA)失平衡的调节作用.方法:采用不可预知的情绪应激刺激方法,刺激大鼠21d,建立CES焦虑模型.电针"百会"、"三阴交"穴治疗21d,运用荧光分光光度法测定大鼠海马、大脑皮质单胺神经递质5-羟色胺(5-HT)、去甲肾上腺素(NE)和多巴胺(DA)的含量,用免疫组化法检测两脑区GABA的表达.结果:模型组较空白组大鼠海马和大脑皮质5-HT、NE和DA的含量明显升高、GABA平均光密度(AOD)值明显降低(P<0.05,或P<0.01);电针可降低模型大鼠两脑区单胺递质含量、上调其GABA表达(P<0.05或P<0.01).结论:电针抗焦虑作用可能与调节两类神经递质间的失平衡相关.
|
| 关 键 词： | 电针 慢性情绪应激 焦虑 |
Regulation effects of electro-acupuncture on monoamine neurotransmitter and GABA in rats with chronic emotional stress-induced anxiety |
| |
| ZHOU Qi-zhi,ZHAO Ji-lan,CAI Ding-jun,YU Shu-guang,WEI Jiao-lu,WU Qiao-feng,PENG Xiao-hua,WANG Wei,XU Hai-yang.Regulation effects of electro-acupuncture on monoamine neurotransmitter and GABA in rats with chronic emotional stress-induced anxiety[J].China Journal of Traditional Chinese Medicine and Pharmacy,2008,23(10). |
| |
| Authors: | ZHOU Qi-zhi ZHAO Ji-lan CAI Ding-jun YU Shu-guang WEI Jiao-lu WU Qiao-feng PENG Xiao-hua WANG Wei XU Hai-yang |
| |
| Institution: | ZHOU Qi-zhi,ZHAO Ji-lan,CAI Ding-jun,YU Shu-guang,WEI Jiao-lu,WU Qiao-feng,PENG Xiao-hua,WANG Wei,XU Hai-yang(Laboratory of Acu-moxibustion,College of Acu-moxibustion , Tuina,Chengdu University of TCM,Chengdu 610075,China) |
| |
| Abstract: | Objective:To research the regulation effects of electro-acupuncture(EA)on the monoamine neurotransmitter and GABA in rat with chronic emotional stress-induced anxiety.Methods:Chronic emotional stress anxiety model was established by using chronic unpredictable emotional stress methods for 21 days.EA was applied to Baihui(GV20)and Sanyinjiao(SP6) and lasted for 21 days.The contents of 5-HT,NE and DA in the hippocampus and the cerebral cortex were measured by fluorospectrophotometry.The content of GABA in the... |
| |
| Keywords: | 5-HT NE DA GABA |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
