乳腺癌与ALDH1相关性研究的现状

目的：总结近年来关于乙醛脱氢酶1（acetaldehyde dehydrogenase 1，ALDHl）特点的研究及其作为乳腺癌干细胞标志的相关性研究。方法：应用PubMed、Elsevier Sciencedirect和CNKI期刊全文数据库，以“乳腺肿瘤、ALDH1、干细胞、免疫组织化学、蛋白质组学”为关键词，检索2002—01—2012—11相关文献，共检索到256篇。排除标准：非乳腺癌和非ALDH1。纳入标准：1）ALDH1与乳腺癌的相关性研究；2）免疫组织化学方法及蛋白质组学研究乳腺癌干细胞。根据排除标准和纳入标准符合分析的文献18篇。结果：应用免疫组织化学、蛋白质组学和临床试验等方法的大量研究结果表明，ALDH1细胞能满足干细胞的定义标准，具有自我更新和多向分化的特性，并且已经在多种组织中证实了AL—DH1是一种有效的干细胞通用标志，兼之检测方法的多样化，使之成为多种组织类型干细胞鉴定和分离的有力工具，在干细胞研究领域具有特别重要的意义。作为乳腺癌干细胞标志之一，ALDH1与多种临床病理因素相关，在一定程度上可以反应疾病的恶性程度及预后，是导致乳腺癌发生、进展、耐药、复发和预后不良的根源，在临床上有非常重要的指导意义。结论：ALDH1可能具有自身独立的生物学特性，进一步深入研究其作为乳腺癌干细胞的特性，有助于发现新的关于ALDH1的靶点，为乳腺癌的个体化治疗提供理论依据。

Current situation of correlation analysis between breast cancer and ALDH1

OBJECTIVE： To sum up the characteristic of Aldehyde dehydrogenase 1 and the association study that ALDH1 as the stern cell marker of breast cancer in recent years. METHODS： The following keywords：breast tumor, AL DHl,stem cell, immunohistochemistry proteomics were used and the database of PubMed, Elsevier Sciencedirect and CNKI Academic Journal were searched~ The limited time was 2002.01- 2012-11. Totally 256 related literatures were srarcbed. Standards of getting out： non-breast cancer, non-ALDH1. Enrolled criteria.. 1）The correlation study of breast cancer and ALDH1.2）The method to study breast cancer stem cells was immunohistochemical method and proteomics. Eighteen literatures were included in this review. RESULTS： Many studies which invovled immunohistochemistry, pro- teomics, clinical trials and so on shows that ALDH1 q- cells met the standard definition of stem cells （self proliferation and multi-differentiation）. ALDH1 is confirmed as an effective mark of stem cell in many tissues and can be detected by several methods, which make it a powerful tool in the identification and isolation of stem cells. ALDH1 can make great significance in the field of stem cell research. As one of the marks of breast cancer stem cell,ALDH1 is associated with many clinic- pathological factors,can reflect the degree of malignancy and prognosis of the disease to a certain extent and it was the root of tumorigenesis, progression, drug resistance, and poor prognosis in breast cancer. CONCLUSIONS： With respect to biological characteristics of ALDH1, further investigation on the characteristics as the stem cell marker of breast cancer may help us provide theoretical basis for individualized treatment of breast cancer.