| 绿原酸调节糖脂代谢的作用机制研究进展 |
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| 引用本文： | 庞美蓉,刘零怡,高汪磊,张英. 绿原酸调节糖脂代谢的作用机制研究进展[J]. 中草药, 2015, 46(2): 305-312 |
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| 作者姓名： | 庞美蓉 刘零怡 高汪磊 张英 |
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| 作者单位： | 浙江大学生物系统工程与食品科学学院, 浙江省农产品加工技术研究重点实验室, 浙江省食品加工技术与装备工程中心, 浙江 杭州 310058;浙江大学生物系统工程与食品科学学院, 浙江省农产品加工技术研究重点实验室, 浙江省食品加工技术与装备工程中心, 浙江 杭州 310058;浙江大学生物系统工程与食品科学学院, 浙江省农产品加工技术研究重点实验室, 浙江省食品加工技术与装备工程中心, 浙江 杭州 310058;浙江大学生物系统工程与食品科学学院, 浙江省农产品加工技术研究重点实验室, 浙江省食品加工技术与装备工程中心, 浙江 杭州 310058 |
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| 基金项目： | 国家"973"计划项目(2012CB720806);浙江大学馥莉食品研究院基金(KY201303) |
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| 摘 要： | 绿原酸(CGA)是人类饮食中量较丰富的酚类化合物之一,在植物中分布广泛。据现有研究成果,CGA具有多种药理作用并与人类健康密切相关。其中,CGA改善胰岛素敏感性,调节糖、脂代谢的功效备受研究者的关注,逐渐成为国内外的研究热点。综述了CGA调节糖脂代谢的作用机制研究进展,并对未来的研究方向进行了分析和展望,以期更好地发挥CGA的有益作用,为肥胖、2型糖尿病等慢性疾病的防治提供新思路和新途径。
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| 关 键 词： | 绿原酸 酚类化合物 糖代谢 脂代谢 胰岛素敏感性 |
| 收稿时间： | 2014-06-01 |
Research progress in regulation of chlorogenic acid on glucose and lipid metabolism |
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| PANG Mei-rong,LIU Ling-yi,GAO Wang-lei and ZHANG Ying. Research progress in regulation of chlorogenic acid on glucose and lipid metabolism[J]. Chinese Traditional and Herbal Drugs, 2015, 46(2): 305-312 |
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| Authors: | PANG Mei-rong LIU Ling-yi GAO Wang-lei ZHANG Ying |
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| Affiliation: | College of Biosystems Engineering and Food Science, Zhejiang University, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R&D Center for Food Technology and Equipment, Hangzhou 310058, China;College of Biosystems Engineering and Food Science, Zhejiang University, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R&D Center for Food Technology and Equipment, Hangzhou 310058, China;College of Biosystems Engineering and Food Science, Zhejiang University, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R&D Center for Food Technology and Equipment, Hangzhou 310058, China;College of Biosystems Engineering and Food Science, Zhejiang University, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang R&D Center for Food Technology and Equipment, Hangzhou 310058, China |
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| Abstract: | Chlorogenic acid (CGA) is one of the most abundant phenolic compounds in the human diet and occurs ubiquitously in plant. According to recent research results, CGA exhibits a variety of pharmacologic activities and is closely related to human health. In particular, the biological activities of regulating the metabolism of glucose and lipid and enhancing the sensitivity of insulin of CGA have attracted more and more attention, and gradually become a research hotspot. This article reviewed the research progress in the mechanism of CGA in modulating the effects on glucose and lipids metabolism. Furthermore, the future research direction for CGA is also prospected and presented in order to provide new ideas and approaches for the prevention from obesity, diabetes, and other chronic diseases. |
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| Keywords: | chlorogenic acid phenolics glucose metabolism lipid metabolism insulin sensitivity |
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