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Biocompatibility of silver nitrate and ofloxacine coated bioabsorbable SR-PLLA rods |
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| Authors: | Markku Multanen Martti Talja Teuvo L. J. Tammela Jukka Seppälä Tero Välimaa Kari Järvi Pertti Törmälä |
| Affiliation: | Department of Surgery, P?ij?t-H?me Central Hospital, Keskussairaalankatu 7, FIN-15850, Lahti, Finland e-mail: am.multanen@pp.fimnet.fi Tel.: +358-3-8195330; Fax: +358-3-8192169, FI Division of Urology, Tampere University Hospital, Tampere, Finland, FI Helsinki University of Technology, Espoo, Finland, FI Tampere University of Technology, Institute of Biomaterials, Tampere, Finland, FI |
| Abstract: | The purpose of this study was to evaluate the biocompatibility of silver nitrate and ofloxacine coatings of bioresorbable self-reinforced poly-l-lactic acid (SR-PLLA) rods. SR-PLLA rods coated with pure poly(caprolactone-co-l-lactide) or blended with silver nitrate (10, 5 or 2 weight-%) or ofloxacine (5 or 2 weight-%) were implanted in the dorsal muscles of 25 male rabbits. Tissue reactions caused by implantation trauma were seen 1 week after implantation. The positive control and 10 w-% silver nitrate coating showed the most marked reactions 1 month after implantation. Only sparse reactions were seen 6 months after implantation. Tissue reactions were scored semi-quantitatively. As a result of this study, we concluded that silver nitrate or ofloxacine coatings up to five w-% did not alter the good biocompatibility of SR-PLLA essentially. The method may lead to the possibility of preventing bacterial adhesion to urological stents during insertion. Received: 23 August 2000 / Accepted: 6 December 2000 |
| Keywords: | Bioabsorbable Stent Infection |
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