原发性免疫球蛋白A肾病预后因素与左室肥厚的相关分析

目的:探讨原发性免疫球蛋白A肾病(IgAN)的临床及病理预后因素与患者左室肥厚的相关性.方法:收集整理79例原发性IgAN患者与预后有关的临床及病理资料及每例患者的左室质量指数.根据左室质量指数将所有IgAN患者分为左室肥厚组与非左室肥厚组,分别比较2组各个的临床病理指标的差异性,并将左室质量指数分别与这些临床病理指标作单因素相关性分析.结果:左室肥厚组的血肌酐,肾小球滤过率,血尿酸,24 h尿蛋白定量,收缩压,舒张压水平显著高于非左室肥厚组,肾小球硬化,间质纤维化,系膜增生,肾小管萎缩和动脉硬化水平也显著高于非左室肥厚组.单因素相关分析显示左室质量指数与上述临床病理指标呈明显正相关.结论:原发性IgAN患者的左室肥厚可能与决定该病预后的临床病理因素有关.

Correlation Analysis of the Prognostic Factors of Primary IgAN and Left Ventricular Hypertrophy

Objective：To investigate the association between the prognostic factors of primary IgAN and left ventricular hypertrophy. Methods：We divided 79 patients with primary IgAN into LVH group and non-LVH group,and compared the clinical and pathological prognostic factors between the two groups.The univariate correlation were also analysed between LVMI and all prognostic factors,respectively.Results：The levels of serum creatinine,eGFR,uric acid,24h urine protein,systolic pressures, diastolic pressures,glomerular sclerosis,interstitial fibrosis,mesangial proliferation,tubular atrophy and vascular lesions of LVH group were significantly higher than that of non-LVH group and positively correlated with LVMI.Conclusions： LVH of primary IgAN may be associated with the prognostic factors.