Acute cellular rejection and HLA mismatch in heart transplantation: insights from a developing country |
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| Authors: | Lígia Beatriz Chaves Espinoso Schtruk Tereza Cristina Fellipe Guimarães Luis Cristóvão Pôrto Maria Cristina Caetano Kuschnir Alexandre Siciliano Colafranceschi Paulo Moreira da Silva Filho Andrea De Lorenzo |
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| Affiliation: | 1. Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil;2. Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brazil |
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| Abstract: | The notable evolution of heart transplant (HTX) has paralleled the capacity of diagnosing rejection and, consequently, initiating timely treatment. Acute cellular rejection, diagnosed by endomyocardial biopsy, is the most frequent in the first 6 months after HTX. HLA matching is not routinely performed in HTX due to the absence of consensus regarding its usefulness. However, the use of HLA typing might be underscored if it could predict an increased risk of rejection. Therefore, the aim of this study was to evaluate, at a public cardiology center in Brazil, the association between HLA mismatches and the incidence of acute cellular rejection in the first 6 months after HTX. Data were obtained from hospital records and from the National Transplant System. Overall, there was no association between the number of HLA mismatches and the frequency of acute cellular rejection, but there was a tendency toward a higher incidence of rejection with HLA‐DR incompatibility. |
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| Keywords: | cardiac transplantation
HLA
HLA incompatibility rejection |
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