血清Cys C测定在肾综合征出血热所致ARF中的意义

目的探讨血清胱抑素C（CysC）在肾综合症出血热所致ARF中的意义。方法采用微粒子增强比浊法检测血清CysC浓度、酶法测定血肌酐（Cr）和尿素氮（BUN）,用Cockroft-Gault公式计算内生肌酐清除率（Ccr）。将14例患者在疾病不同时期测定的血Cr、BUN、CysC值进行整理,根据Ccr水平分三组。结果血CysC与Cr之间具有很好的正相关性（r=0.8）,而与Ccr呈负相关（r=-0.598）。血Cr及BUN恢复正常后,仍有40%的病人血清CysC异常。结论与传统指标血Cr及BUN相比,血清CysC测定在ARF病情监测甚至指导临床用药中具有更大优势。

The Value of Serum Cystatin C Detection on Hemorrhagic Fever with Renal Syndrome Induced Acute Renal Failure

Objective To investigate the value of sertrm Cystatin C（CysC） in acute renal failure（ARF） which was induced by hemorrhagic fever with renal syndrome.Methods Particle-enhanced turbidimetric immunoassay （PETIA） was used to test the serum CysC and enzymic method was used to test the serum creatinine （Cr） and urea nitrogen （BUN）. The creatinine clearance （Ccr） was calculated with Cockroft-Gauh formula. The value of blood Cr, BUN and CysC at different stages in 14 patients was arranged and three groups were developed according to the Ccr level. Results Serum Cys C had a good positive correlation with Cr（ r = 0.8） and negative correlation with Ccr（ r = -0.598）.After the recoversion of Cr and BUN,the CysC in 40% patients was still in abnormal level. Conclusion Compared with traditional markers like blood Cr and BUN, the serum Cys C detection showed advantage in observing ARF development and monitoring the treatment strategy.