A new spectinabilin derivative with cytotoxic activity from ant-derived Streptomyces sp. 1H-GS5 |
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| Authors: | Chong-Xi Liu Shuang-He Liu Jun-Wei Zhao Ji Zhang Xiang-Jing Wang Jian-Song Li |
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| Affiliation: | 1. Life Science and Biotechnology Research Center, School of Life Science, Northeast Agricultural University, Harbin 150030, China;2. Department of New Drug Screening, Zhejiang Hisun Pharmaceutical Co., Ltd, Taizhou 318000, China |
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| Abstract: | ![]()
A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50 values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin. |
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| Keywords: | Spectinabilin derivative ant-derived strain Streptomyces sp. 1H-GS5 cytotoxicity |
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