轮状病毒肠炎婴幼儿血清细胞因子与血清25-羟维生素D水平的研究

目的：观察轮状病毒肠炎（ RVE）婴幼儿血清细胞因子与血清25-羟维生素D的水平及临床意义。方法选择轮状病毒肠炎68例婴幼儿作为研究组，同期体检的56名健康婴幼儿作为对照组，分别空腹采集静脉血，测定血清细胞因子及血清25-羟维生素D水平。结果研究组患儿血清白细胞介素（ IL）-2、IL-6、肿瘤坏死因子-α（ TNF-α）明显高于对照组（ P＜0.01），研究组患儿血清25-羟维生素D明显低于对照组（P＜0．05）。结论 RVE患儿血清IL-2、IL-6、TNF-α水平升高与血清25-羟维生素D水平降低具有相关性。

Levels of cytokine and 25-hydroxyvitamin D in the blood of infants with rotavirus enteritis

Objective To explore levels of cytokine and 25-hydroxyvitamin D in the blood of infants with rotavirus enteritis and their clinical significance.Methods Sixty-eight infants with rotavirus enteritis were recruited as the research group, while 56 healthy infants who underwent normal physical checks were assigned as the control group.Fasting venous blood samples were collected for the detection of cytokine and 25-hydroxyvitamin D levels by RP-HPLC method.Results The levels of IL-2, IL-6, TNF-αin the in-fants of the research group were significantly higher than those of the infants of the control group (P<0.01).The level of 25-hydroxyvi-tamin D of the study group was obviously lower than that of the control group (P<0.05).Conclusion The elevated levels of IL-2, IL-6, TNF-αin the infants with rotavirus enteritis were associated with the decreased level of 25-hydroxyvitamin D.