复方丹参治疗中重度新生儿缺氧缺血性脑病的临床研究

目的 :观察新生儿缺氧缺血性脑病 (HIE)血液与脑脊液中内皮素 (ET- 1)、一氧化氮 (NO)、肌酸磷酸激酶脑型同工酶 (CK- BB)的含量变化 ,探讨复方丹参治疗中重度新生儿缺氧缺血性脑病的疗效。方法 :将 6 0例中重度 HIE患儿随机分成治疗组和对照组 ,治疗组在常规治疗的基础上加用复方丹参 ,分别于急性期及恢复期检测血液与脑脊液中 ET- 1、NO、CK- BB的含量 ,观察两组临床疗效的差异。结果 :治疗组显效率及总有效率分别为 80 %及 93.3% ,对照组显效率及总有效率分别为 6 7%及 81% ,治疗组均明显高于对照组。结论 :ET- 1、NO、CK- BB参与了 HIE的病理过程 ,复方丹参治疗中重度新生儿缺氧缺血性脑病有显著效果

Clinical study on HIE treated with composite major Salviae Miltiorrhiza Radix

Objective:To investigate contents of ET-1,NO,CK-BB in blood and CSF in HIE infants,and to study the curative effects of Salviae Mil tiorrhiza Radix on mid or severe HIE infantsMethods:sixty case s of mid or severe HIE infants were divi ded into treatment group and cont rol group.Salviae Miltiorrhiza Rad ix were added in the treatment group except of ordinary treatment.Contents of ET-1, NO,CK-BB in blood and CSF were det ected in acute and convalescence p hase.The clinical effects of the two groups were observedResults:The obviously effective rate and effecti v e rate are 80% and 92% respectively in th e treatme nt group,and the obviously effective rat e and effective rate are 67% and 8 1% respectively in the control groupC onclusion:ET-1,NO,CK-BB are th e pathology factors of HIE.Salviae Miltiorrhiza Radix has obvious eff ects in treating mid or severe HIE infants