| 肾血管性高血压大鼠自发脑卒中 |
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| 引用本文： | 黄如训,曾进胜,苏镇培,陈颖贤,潘勇辉,黎锦如.肾血管性高血压大鼠自发脑卒中[J].中国神经精神疾病杂志,1992(3). |
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| 作者姓名： | 黄如训 曾进胜 苏镇培 陈颖贤 潘勇辉 黎锦如 |
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| 作者单位： | 中山医科大学附属第一医院神经科
(黄如训，曾进胜，苏镇培，陈颖贤，潘勇辉)，中山医科大学附属第一医院神经科(黎锦如) |
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| 摘 要： | 通过研究双肾双夹型肾血管性高血压大鼠自发脑卒中的病理形态,发现高血压所致的脑内细小动脉纤维素样坏死、透明变性和微动脉瘤形成等是出血性脑卒中和脑梗塞的共同病理基础。探讨了高血压动脉硬化性脑卒中的发病机制,并为混合性脑卒中提供了实验依据。
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| 关 键 词： | 脑血管疾病 肾血管性高血压 大鼠 病理学 |
Spontaneous stroke in renovascular hypertensive rats. |
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| Huang Ruxun,et al..Spontaneous stroke in renovascular hypertensive rats.[J].Chinese Journal of Nervous and Mental Diseases,1992(3). |
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| Authors: | Huang Ruxun |
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| Institution: | Huang Ruxun,et al. Department of Neurology The Affiliated First Hospital,Sun Yat-Sen University of Medical Sciences. Guangzhou. 510080 |
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| Abstract: | Renovascular hypertension was pro duced in 55 operated Sprague-Dawley rats by means of the silver clips to constrict bilateral renal arteries in which the inside diameters were about 0.30mm.The incidence of spontaneous stroke in the renovascular hypertensive rats(RHR) was 56.4%(31/55).The pathological changes of the diseased vessels in the RHR with stroke were fibrinoid necrosis,hyalinosis,formation of microaneurysms and hyperplasia of internal or/and external layers of arterioles or small arteries with the thickened mural and stenotic lumen.It was believed that the haemorrhage occurred when the blood vesselsruptured or their permeability increased,and the large or small infarcts occurred due to the occlusion of the blood vessels.Cerebral haemorrhage and infarction may occur in a RHR simultaneously.We concluded that the hypertensive arteriol-osclerosis was the common pathological bases of this two types of stroke. |
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| Keywords: | Cerebral vascular diseases Renovascular hypertension Rat Pathology |
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