| 正清风痛宁肠溶片在犬体内的药动学及绝对生物利用度研究 |
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| 引用本文： | 王柯静,周远大,何海霞,冯晓科,康纪平,李秋波.正清风痛宁肠溶片在犬体内的药动学及绝对生物利用度研究[J].中药药理与临床,2008,24(6). |
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| 作者姓名： | 王柯静 周远大 何海霞 冯晓科 康纪平 李秋波 |
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| 作者单位： | 1. 重庆医科大学附属第一医院临床药理研究室,重庆,400016
2. 四川都江堰养麝研究所,都江堰,611830 |
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| 摘 要： | 目的:研究了正清风痛宁肠溶片在犬体内的药代动力学及绝对生物利用度.方法:采用双周期自身交叉设计,10只Beagle犬分别静脉及口服给予正清风痛宁肠溶片10mg/kg,HPLC法测定血浆中的药物浓度,3p97软件计算二者药动学参数和绝对生物利用度.结果:犬静注给予青藤碱后,药-时曲线呈二室模型,T1-2β为106.67±12.2min,AUC0-t为(93.32±8.07)μg/min·ml.犬口服正清风痛宁肠溶片后,药-时曲线为一室模型,T1/2(ka)为(36.0±7.97)min,T1/2(ka)为(84.77 4-19.33)min,Tmax为(79.27±15.62)min,Cmax为(0.18±0.049)μg/ml,AUC0-1为(38.51±13.23)μg/min·ml.口服青藤碱的绝对生物利用度为41.26%.结论:正清风痛宁肠溶片生物利用度较高,在临床能产生较好的疗效.
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| 关 键 词： | 青藤碱 正清风痛宁肠溶片 药动学 绝对生物利用度 |
Pharmacokinetics and absolute bioavailability of Zhengqing Fengtongning Enteric Tablets(正清风痛宁肠溶片) in Beagle dogs |
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| Wang Kejing,Zhou Yuanda,He Haixia,Feng Xiaoke,Kang Jiping,Li Qioubo.Pharmacokinetics and absolute bioavailability of Zhengqing Fengtongning Enteric Tablets(正清风痛宁肠溶片) in Beagle dogs[J].Pharmacology and Clinics of Chinese Materia Medica,2008,24(6). |
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| Authors: | Wang Kejing Zhou Yuanda He Haixia Feng Xiaoke Kang Jiping Li Qioubo |
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| Institution: | Wang Kejing,Zhou Yu,a,He Haixia,Kang Jiping1,Feng Xiaoke1,Li Qioubo1(Clinical Pharmacology Laboratory,The First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing 400016,1 Sichuan Institute of Research Deer,Dujiangyan 611830) |
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| Abstract: | Objective:To investigate the pharmacokinetic characteristics of Zhengqing Fengtongning enteric tablets and its absolute bioavailability in Beagle dogs.Method:According to a randomized two-period crossover design,ten Beagle dogs were administrated by iv or po 100mg sinomenine respectively with a 7-day washout,whose plasma sinomenine level was measured by HPLC.The pharmacokinetic parameters and bioavailability of enteric tablets were calculated by 3p97 software.Result:The pharmacokinetics behavior of sinomeni... |
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