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| 交感神经化学切除后大鼠心窦房结区神经递质的变化 | |
| 引用本文： | 于苏国 王健本. 交感神经化学切除后大鼠心窦房结区神经递质的变化[J]. 解剖学报, 1994, 25(4): 364-368,T007,8 |
| 作者姓名： | 于苏国 王健本 |
| 作者单位： | 同济医科大学解剖学教研室 |
| 摘 要： | 用６－羟多巴胺化学切除大鼠心内交感神经后，有免疫组织化学结合图像分析法和放免测定观察窦房结区神经肽Ｙ及降钙素基因相关肽的变化；同时应用组织化学方法结合图像分析、生物化学测量观察了ＳＡＮ区去甲肾上腺素及乙酰胆碱酯酶的变化，实验发现，静脉注射６－ＯＨＤＡ５０ｍｇ／ｋｇ一周后，ＳＡＮ区ＮＡ及ＮＰＹ含量明显减少，ＡＣＨＥ活性显著增加，ＣＧＲＰ含量增加不明显。 |
| 关 键 词： | 神经肽 窦房结 交感神经 组织化学 |
CHANGES OF NEUROTRANSMITTERS IN RAT HEART SINOATRIAL NODE REGION AFTER CHEMICAL SYMPATHECTOMY |
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| Yu Suguo, Wang Jianben. CHANGES OF NEUROTRANSMITTERS IN RAT HEART SINOATRIAL NODE REGION AFTER CHEMICAL SYMPATHECTOMY[J]. Acta Anatomica Sinica, 1994, 25(4): 364-368,T007,8 | |
| Authors: | Yu Suguo Wang Jianben |
| Abstract: | The changes of some neurotransmitters in the sinoatrial(SA) node region of the rat heart after chemical sympathectomy with 6-hydroxydopamine were studied.Quantitative analysis for neuropeptide Y(NPY)and calcitonin gene-related peptide(CGRP)in the SA node region was perfromed by immunohistochemistry,image analysis and radioimmunoassay.Meanwhile,the levels of noradrenaline(NA)and acetylcholinesterase(AChE)in the SA node region were performed by histochemistry,image analysis and biochemical methods,One week after intravenous administration of 50 mg/kg of 6-hydroxydopamine,significant reduction in the levels of both NA and NPY were observed.Treatment with 6-hydroxydopamine cause marked increase of ACHE activity and slight increase of CGRP level. |
| Keywords: | Neuropeptide Sino-atrial node Heart Sympathectomy Histochemistry Rat |
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