湛江市静脉内毒瘾者感染HCV和肝功能分析

目的　为了解湛江市吸毒者感染HCV、HBV和肝功能损害情况。　方法　作者于 2 0 0 0年 2月～ 2 0 0 1年 5月采用ELISA和赖氏法对湛江市东坡岭戒毒所的静脉吸毒者 716例 ,非静脉吸毒者 80 4例作了HCV、HBV血清学和肝功能检测。　结果　发现静脉吸毒组HCV感染率为 40 .3 6% ,是非静脉吸毒组感染HCV的 4.16倍 ,肝功能异常率分别为2 3 .46%、7.5 9%。静脉吸毒组感染HCV和肝功能损害的危险性明显高于非静脉吸毒组 ,差异有高度显著性 (P <0 .0 1)。　结论　静脉吸毒人群HCV的感染流行可能与合用注射器和毒品溶剂有关 ;吸毒及HCV感染会造成肝功能损害。

AN Analysis of HCV Infection and ALT Alteration in Intravenous Drug Addicts in Zhanjiang City

Objective To understand the prevalence of HCV and HBV infection and abnormal ALT in intravenous drug addicts in Zhanjiang city. Methods A total of 716 intravenous drug addicts and 804 non-intravenous drug addicts in Dong-po-lin drug abstaining center were measured on HCV, HBV and ALT by ELISA and enzymatic method from Feb.2000 to May.2001. Results HCV infection rate of intravenous drug addict group was 40.36%, which was 4.16 times that of non-intravenous drug addicts group(P<0.01). Abnormal ALT rates in two groups were 23.46% and 7.59%, respectively. There was statistical significance between two groups (P<0.01). Conclusions The high rates of HCV infection and ALT alteration may come from sharing injector and solvent for drugs. Drug and HCV infection can result in ALT alteration.