奥美拉唑治疗老年人反流性食管炎

目的：观察奥美拉唑对我国老年人反流性食管炎的疗效。方法：老年人反流性食管炎４５例，男性４１例，女性４例，年龄７５±ｓ５ａ，单以奥美拉唑２０ｍｇ，ｐｏ，ｑｄ，治疗８ｗｋ。结果：治疗８ｗｋ临床全部有效，内镜检查的愈合率９３％，愈合者停药２ｍｏ，６ｍｏ，１２ｍｏ累积复发率分别为６０％，８２％，９１％；３９例复发者１５例需２０ｍｇ，ｑｄ，１９例需２ｄ服２０ｍｇ，５例需３ｄ服２０ｍｇ维持治疗，观察３～１２ｍｏ，症状缓解率分别为１００％，８９％，６０％。结论：奥美拉唑对我国老年人反流性食管炎的近期及维持治疗均有良好疗效，但停药后复发率高，需维持治疗，且维持剂量不宜过低

Omeprazole in treating reflux esophagitis in aged

AIM:To study the efficacy of omeprazole for therapy of reflux esophagitis in aged. METHODS:Forty-five patients(M41,F4,age 75 ± 5 a) with reflux esophagitis(SavaryMiller,grade Ⅰ, 7 cases; grade Ⅱ,31 cases;grade Ⅲ, 6 cases;grade Ⅳ,1 case) were treated with omeprazole 20 mg po,qd,for 8 wk.RESULTS:After 8 wk the clinical total effective rate was 100 %. The endoscopic healing rate was 93%.The incidence of pulmonary complication of reflux esophagitis was significantly reduced than before treatment(44 % vs 4 % ,P< 0. 01).Forty-three cases of healing patients were stopped omeprazole treatment,their cumulative recurrent rates at 2,6, 12 mo were 60%, 81% and 91%,respectively. Four patients(gradeⅠ) had not recurred only. The 39 recurrent patients were treated with omeprazole of 20 mg qd again. After symptom remitting, the lower doses of omeprazole for maintaining treatment that suppresses symptom were 20 mg qd in 15 patients, 20 mg every other day in 19 patients and 20 mg each 3days in 5 patients. After maintaining treatment 3-12 mo, continually symptomatic remittent rates were 100%, 89%,and 60%, respectively. The adverse reactions of omeprazole were slight.CONCLUSION :The results showed that efficacy of omeprazole in short term and maintaining treatment for elderly reflux esophagitis is satisfactory,but recurrent rates is very high after stopping treatment.Therefore maintaining treatment is unsuitable with lower dose.