Immunological Reconstitution in Children After Completing Conventional Chemotherapy of Acute Lymphoblastic Leukemia is Marked by Impaired B‐cell Compartment |
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| Authors: | Minna Koskenvuo MD PhD Ilse Ekman BS Emmi Saha BM Ellinoora Salokannel MD Jaakko Matomäki PhD Jorma Ilonen MD PhD Leena Kainulainen MD PhD Mikko Arola MD PhD Päivi Maria Lähteenmäki MD PhD |
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| Institution: | 1. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland;2. Division of Pediatric Hematology and Oncology and Stem Cell Transplantation, Department of Pediatrics, Children's Hospital, University of Helsinki, Helsinki, Finland;3. Immunogenetics Laboratory, University of Turku, Turku, Finland;4. Clinical Research Centre, Turku University Hospital, Turku, Finland;5. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Tampere University Hospital, Tampere, Finland |
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| Abstract: | Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard‐risk (SR) or intermediate‐risk (IR) acute lymphoblastic leukemia (ALL). Both naïve and memory B cells were most severely affected and showed slow recovery during the 2‐year follow‐up, while the T‐cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine‐preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B‐cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function. |
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| Keywords: | B cell chemotherapy immune recovery leukemia T cell |
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