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Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy‐Induced Nausea and Vomiting in Children With Cancer |
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| Authors: | Jacqueline Flank BScPhm ACPR MSc Paula D Robinson MD MSc Mark Holdsworth PharmD Robert Phillips MD Carol Portwine MD FRCPC PhD Paul Gibson MD Cathy Maan PhD CPsych Nancy Stefin Hons BA CLSt Dipl CCLS Lillian Sung MD PhD L Lee Dupuis MScPhm ACPR PhD |
| Institution: | 1. Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada;2. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada;3. Pediatric Oncology Group of Ontario, Toronto, Canada;4. College of Pharmacy, University of New Mexico, Albuquerque, New Mexico;5. Regional Department of Haematology and Oncology, Leeds Children's Hospital, Leeds, United Kingdom;6. Centre for Reviews and Dissemination, University of York, York, United Kingdom;7. Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, Canada;8. Pediatric Hematology/Oncology, Children's Hospital, London Health Sciences Centre, London, Canada;9. Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada;10. Research Institute, The Hospital for Sick Children, Toronto, Canada |
| Abstract: | This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy‐induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence‐based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation. |
| Keywords: | chemotherapy‐induced nausea chemotherapy‐induced vomiting clinical practice guideline supportive care |