Carnosine and related compounds inhibit chemiluminescence of human plasma lipoproteinsin vitro

The antioxidant activity of carnosine and related compounds (5 and 10 mM) is assessed from the chemiluminescence curve using a model of Fe-initiated lipid peroxidation of human serum apoB-lipoproteins. These agents lower to different degrees the amplitudes of “fast” and “slow” bursts, the reaction rate, and the chemiluminescence light sum; the latency is prolonged, which may occur upon reduction of lipid hydroperoxides and/or inactivation of free radicals. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 152–154, February, 1995 Presented by I. P. Ashmarin. Member of the Russian Academy of Medical Sciences