单侧与双侧顺行性脑灌注对认知能力的影响

目的　比较全主动脉弓置换术中应用单侧顺行性脑灌注和双侧顺行性脑灌注对认知能力的影响。方法　 16例全主动脉弓置换术患者按随机数字表法随机分为单侧顺行性脑灌注组和双侧顺行性脑灌注组 ,每组各 8例。两组均行术前、术后神经系统物理检查、颅脑计算机体层摄影 (CT)和认知能力测验比较。　结果　无手术及近期死亡 ,无新发脑梗塞出现。两组各有 1例出现短暂性神经功能异常 ,两组间术前和术后的认知能力比较差别无统计学意义 (P>0 .0 5 )。　结论　在基底动脉环完整、存在有效侧枝循环的条件下 ,单侧顺行性脑灌注及双侧顺行性脑灌注均能取得良好的效果 ,两种脑保护方法对认知能力的影响无统计学意义。

Prospective Randomised Neurocognitive Study of Unilateral and Bilateral Antegrade Selective Cerebral Perfusion for Total Aortic Arch Replacement

ObjectiveTo compare the cerebral protective effect of unilateral and bilateral antegrade selective cerebral perfusion during total aortic arch replacement, particularly with respect to neuropsychological outcome.MethodsFrom June 2003 to March 2004, 16 patients who underwent total aortic arch replacement were randomly allocated to one of two methods of brain protection: unilateral antegrade selective cerebral perfusion (unilateral group, n =8) or bilateral antegrade cerebral perfusion (bilateral group, n =8). Preoperative and postoperative neurological examination, brain computed tomography(CT) scan, and cognitive function tests were performed.ResultsAll patients survived the operations and were discharged from hospital. No new brain infarction occurred. Transient neurologic dysfunction occurred in 1 patient of each group. There were no intergroup differences in the scores of preoperative and post operative cognitive function ( P >0.05).ConclusionBoth methods of brain protection for patients undergoing total aortic arch replacement result in favorable and similar effect of brain protection in term of cognitive function provided the circle of Willis is patent and collateral flow is adequate.