| 清凉巴布剂的抗炎作用及机制研究 |
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| 引用本文： | 夏勤,郑雪平,张兴德,周玲玲.清凉巴布剂的抗炎作用及机制研究[J].安徽医药,2010,14(3):268-270. |
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| 作者姓名： | 夏勤 郑雪平 张兴德 周玲玲 |
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| 作者单位： | 南京市中医院,药剂科,江苏,南京,210001;南京市中医院,肛肠科,江苏,南京,210001;南京中医药大学药学院,江苏,南京,210046 |
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| 基金项目： | 江苏省中医药局课题(NoHL07066) |
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| 摘 要： | 目的研究清凉巴布剂的抗炎作用及作用机制。方法采用二甲苯所致小鼠耳肿胀及角叉菜胶所致大鼠足肿胀，考察清凉巴布剂的抗炎作用，试剂盒检测足肿胀大鼠炎性组织中SOD、MDA、IL-1的含量。结果清凉巴布剂中剂量和高剂量对小鼠耳肿胀及大鼠足肿胀均有显著的抑制作用，可明显降低炎性组织中IL-1、MDA含量，提高SOD活性。结论清凉巴布剂具有良好的抗炎作用，其机制与抑制炎性细胞因子、抗自由基损伤有关。
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| 关 键 词： | 清凉巴布剂 抗炎 白细胞介素-1 丙二醛、超氧化物歧化酶 |
Anti-inflammatory effect of cataplasm of cool plaster and its mechanism |
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| XIA Qin,ZHENG Xue-ping,ZHANG Xing-de,ZHOU Ling-ling.Anti-inflammatory effect of cataplasm of cool plaster and its mechanism[J].Anhui Medical and Pharmaceutical Journal,2010,14(3):268-270. |
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| Authors: | XIA Qin ZHENG Xue-ping ZHANG Xing-de ZHOU Ling-ling |
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| Institution: | 1.Department of Pharmacy;Nanjing Hospital;Chinese Medicine;Nanjing 210001;2.Anorectum Section;NanjingHospital of Traditional;3.Pharmacy College;Nanjing University of TCM;Nanjing 210046 |
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| Abstract: | Aim To investigate the anti-inflammatory effect and mechanism of cataplasm of cool plaster.Method Dimethylbenzene-induced ear swelling in mouse and Carrageenan-induced rat paw edema model in rat were used to observe the anti-inflammatory effect of cataplasm of cool plaster.the content of SOD,MDA and IL-1 in the inflammatory tissue extracts were measured.Results Cataplasm of cool plaster significantly suppressed the ear edema in mice and paw edema in rats.The content of IL-1 and MDA in the inflammatory tissu... |
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| Keywords: | cataplasm of cool plaster anti-inflammatory IL-1 MDA SOD |
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