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淡水溺水后犬肺泡表面活性物质的变化
引用本文:张利东,徐建国,周志强. 淡水溺水后犬肺泡表面活性物质的变化[J]. 医学研究生学报, 1993, 0(Z1)
作者姓名:张利东  徐建国  周志强
作者单位:金陵医院麻醉科,金陵医院麻醉科,金陵医院麻醉科
摘    要:
用杂种犬14只复制淡水溺水的动物模型,分别测定直接和间接损伤后肺组织肺泡表面活性物质的含量。损伤后肺泡表面活性物质含量均见降低,且因各损伤时期、损伤方式而各不相同(P<0.01),结合损伤各期肺组织的病理表现,可见呈一定的相关性。表明肺泡表面活性物质在维持肺正常生理功能过程中有重要意义,并为临床成人呼吸窘迫综合征(ARDS)的表面活性物质替代疗法提供了一定的依据。

关 键 词:淡水溺水  肺泡表面活性物质  直接损伤  间接损伤

Changes of lung surfactant in dogs after fresh water drowning
Zhang Lidong. Changes of lung surfactant in dogs after fresh water drowning[J]. Bulletin of Medical Postgraduate, 1993, 0(Z1)
Authors:Zhang Lidong
Affiliation:Department of Anesthesiology
Abstract:
Lung surfactant(LS) was detected in 14 dogs suffered direct and indirect pulmonary injuries induced by fresh water drowning.LS decreased after injury and was different from the periods of injury(P<0.01).We also found that the reduction of LS had a relevance with the pulmonary pathology.L.S was important in mantaining normal pulmonary function.This experiment may be helpful for the therapy of ARDS.
Keywords:lung surfactant  fresh water drowning  direct injury  indirect injury
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