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Effect of glycodelin on the production of vascular endothelial growth factor in cumulus cells
Authors:Hayes Ellen C  Dominguez Celia E  Voelkel Steven  Song Mingqing  Shanti Aida S  Murphy Ana A
Affiliation:a Emory Center for Reproductive Medicine and Fertility, Division of Reproductive Endocrinology and Infertility, Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia
b Atlanta Center for Reproductive Medicine, Woodstock, Georgia
c Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Arkansas, Little Rock, Arkansas
Abstract:
Glycodelin modulates vascular endothelial growth factor (VEGF) production in cumulus cells in vitro. Patients with normal gonadotropin responses who were undergoing IVF demonstrated increased VEGF production to glycodelin, whereas poor responders had a decreased response to glycodelin.
Keywords:
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