| Otoconin 90蛋白在豚鼠内耳的表达 |
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| 引用本文： | 贾宏博,张清俊,谢溯江,郑颖娟,姚钦,陈姗,刘琳,田大为,吴旻. Otoconin 90蛋白在豚鼠内耳的表达[J]. 中华耳科学杂志, 2011, 9(3): 331-333 |
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| 作者姓名： | 贾宏博 张清俊 谢溯江 郑颖娟 姚钦 陈姗 刘琳 田大为 吴旻 |
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| 作者单位： | 1. 北京空军航空医学研究所 北京 100142
2. 空军后勤部门诊部 北京 100720 |
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| 基金项目： | 国家自然科学基金面上项目(30871220)资助 |
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| 摘 要： | 目的观察Otoconin 90蛋白在内耳的表达情况,探讨其在耳石代谢中的意义。方法采用免疫组织化学SP方法 (streptavidin-perosidase,链霉菌抗生物素蛋白-过氧化物酶连结法)检测正常豚鼠内耳切片各主要部位Otoconin 90表达情况。结果 Otoconin 90蛋白不只在椭圆囊和球囊囊斑的感觉上皮有表达,在与其临近和相对位置的非感觉上皮,以及壶腹、半规管和耳蜗等多个部位均有丰富表达,在椭圆囊和球囊囊腔、半规管内等也有染色阳性物质出现。结论 Otoconin 90蛋白在内耳呈现出"多点"表达的特点,提示内耳多处产生Otoconin 90,可能最后转运至椭圆囊和球囊囊斑,在此与钙离子相互作用形成耳石。
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| 关 键 词： | 耳石 Otoconin 90 内耳 |
Expresssion of otoconin 90 in guinea pigs inner ear |
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| JIA Hong-bo,ZHA NG Qing-jun,XIE Su-jiang,ZHEN Y ing-juan,YAO Qin,CHEN Shan,LIU Ling,TIAN Da-wei,WU Min. Expresssion of otoconin 90 in guinea pigs inner ear[J]. Chinese Journal of Otology, 2011, 9(3): 331-333 |
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| Authors: | JIA Hong-bo ZHA NG Qing-jun XIE Su-jiang ZHEN Y ing-juan YAO Qin CHEN Shan LIU Ling TIAN Da-wei WU Min |
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| Affiliation: | JIA Hong-bo1,ZHANG Qing-jun1,XIE Su-jiang1,ZHEN Ying-juan1,YAO Qin1,CHEN Shan1,LIU Ling1,TIAN Da-wei1,WU Min2 1 Institute of Aviation Medicine,Air Force Beijing 100142,China 2 Policlinic of Logistics Department,Air Force,PLA,Beijing 100720,China |
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| Abstract: | Objective To examine expression of otoconin 90 in the guinea pig inner ear and assess its role in otoconia metabolism.Methods Inner ear sections from normal guinea pigs were immunohistochemically stained using the SP(streptavidin-perosidase) method to detect expression of otoconin 90 and examined under a microscopy.Results Expression of otoconin 90 was seen not only in the macula sensory epithelium of the utricle and saccule,but also in their neighboring and opposing opposite nonsensory epithelium of them.I... |
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| Keywords: | Otoconia Otoconin 90 Inner ear |
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