急性脑梗死患者血清白细胞介素6与白细胞介素8水平的变化及其临床意义

目的 观察急性脑梗死患者血清白细胞介素6（IL-6）、IL-8水平的变化及其意义. 方法 采用免疫酶联吸附法检测90例急性脑梗死患者（急性脑梗死组）与30名健康人（对照组）的血清IL-6和IL-8水平,并按临床神经功能缺损程度评分标准对急性脑梗死患者进行评分,分组比较. 结果 急性脑梗死组血清IL-6和IL-8水平分别为（47.45±15.89）、（57.73±43.88）ng/L,明显高于对照组[分别为（8.93±1.87）、（12.30±2.50）ng/L,P＜0.01],重型神经功能缺损患者（20例）血清IL-6和IL-8水平分别为（78.45±28.34）、（88.6±10.9）ng/L,明显高于中型（36例）、轻型（34例）患者[中型为（41.56±14.34）、（55.20±5.90）ng/L,轻型为（25.78±12.34）、（34.30±8.90）ng/L],均P＜0.05],中型神经功能缺损患者血清IL-6和IL-8水平明显高于轻型（P＜0.05）. 结论 急性脑梗死患者血清IL-6和IL-8水平明显增高,血清IL-6和IL-8升高的程度与神经功能缺损程度密切相关.

Changes and clinic significance of levels of serum interleukin 6 and interleukin 8 in patients with acute cerebral infarction

Objective To observe the changes and clinic significance of levels of serum interleukin 6(IL-6)and interleukin 8(IL-8)in patients with acute cerebral infarction. Methods The serum level of IL-6 and IL-8 of 90 patients with acute cerebral infarction and 30 healthy persons was measured by enzyme-linked immunosorbent assay(ELISA).All the patients were scored by clinic neurological function deficit scale(NDS),and comparision was made among the groups. Results The serum level of IL-6 and IL-8 of the patients was significantly higher than that of the normal control(P ＜ 0.01),and the serum level of IL-6 and IL-8 of the group with serious cerebral infarction was significantly higher than the groups with middle and mild cerebral infarction(P ＜ 0.05),the serum level of IL-6 and IL-8 of the group with middle cerebral infarction was significantly higher than the groups with mild cerebral infarction(P ＜ 0.05). Conclusions Serum levels of IL-6 and IL-8 increase markedly in patients with acute cerebral infarction.The elevation is closely related to the degree of neurological impairment.